Se kilde til Charcot–Marie–Tooths sygdom

=Synonymer=
CMT, neuropati, Charcot–Marie–Tooth disease, Charcot–Marie–Tooth neuropathy, hereditary motor and sensory neuropathy (HMSN), peroneal muscular atrophy (PMA) 

=Beskrivelse=
Arvelig lidelse der rammer PNS med progressivt tab af muskelvæv og følesans

=Forekomst=
1:2500

=Symptomer=
Begynder som regel i den tidlige voksenalder men kan vente til 30-40 års alderen. Første symptom er som regel dropfod.

=Årsag=
Duplikation af en stor region på den korte arm af kromosom 17 (75% af CMT) som indeholder genet PMP22.

=Klassifikation=

'''Clinical categories'''
{| class="wikitable" style="text-align: left;"
|-
! Type
! style="width:13em"|Name
! style="width:16em"|Incidence
! Notes
|-
| '''CMT1'''
| Demyelinating type
| Affects approximately 30% of CMT patients
| Causes severe [[demyelination]], thereby impairing [[nerve conduction velocity]].
|-
| '''CMT2'''
| Axonal type
| Affects approximately 20–40% of CMT patients
| Mainly affects [[axon]]s. Tends to affect lower extremities more than upper extremities. Clinical symptoms are often less severe than in CMT1. As it is an [[axonopathy]], average [[nerve conduction velocity]] is usually not affected (sometimes slightly below normal but mostly above 38 [[metre per second|m/s]]).
|-
| '''CMT3'''
| [[Dejerine-Sottas disease]]
| Very rare
| Does not impair [[nerve conduction velocity]].
|-
| '''CMT4'''
| Spinal type
| 
|
|-
| '''CMT5'''
| Pyramidal type
| 
| 
|-
| '''CMT6'''
|
| 
|
|-
| '''CMTDI'''
| Dominant intermediate type
| 
|
|-
| '''CMTRI'''
| Recessive intermediate type
| 
|
|-
| '''CMTX'''
| X-linked type
| Affects approximately 10–20% of CMT patients
| This type encompasses all CMT forms that are inherited in an [[X-linked]] manner. Average [[Nerve conduction velocity|NCV]]: 25–40 [[Metre per second|m/s]].
|-
|}



[[Kategori:Dropfod]]